Rabbit anti-Human CD1c Monoclonal Antibody for FC - P29017

Core Product Specifications and Parameters

Biological Background: CD1c Function and Localization

• CD1c is a T-cell surface glycoprotein that functions as an antigen-presenting molecule, binding self and non-self lipid and glycolipid antigens.
• It presents lipid antigens to T-cell receptors on natural killer T (NKT) cells, playing a role in adaptive immunity.
• The protein localizes to the cell membrane, endosome membrane, and lysosome, consistent with its role in lipid antigen trafficking.
• CD1c is expressed on cortical thymocytes and in certain T-cell leukemias, with broad tissue distribution.
• Key structural features include an immunoglobulin domain, disulfide bonds, and a transmembrane helix; the protein is glycosylated.
• The calculated molecular weight of the mature protein is approximately 38 kDa (UniProt P29017: 37,654 Da).

Experimental Guidance and Technical Tips

• This antibody is provided pre-conjugated with ABflo® 647, a far-red fluorophore suitable for flow cytometry (FC). Titrate the antibody to determine the optimal working dilution for your specific cell model.
• As CD1c is a membrane protein, ensure appropriate staining protocols for surface and intracellular detection; consider fixation and permeabilization conditions if targeting intracellular compartments.
• Validate reactivity using known CD1c-positive cell lines or primary cells (e.g., human thymocytes, BDCA1+ dendritic cells) and include proper isotype controls and Fc receptor blocking to minimize nonspecific binding.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. This anti-CD1c (BDCA1) antibody exemplifies our commitment to supplying high-quality reagents for T-cell immunology and oncology research. Beyond individual antibodies, we facilitate procurement of validated antibody pairs, optimized monoclonal and polyclonal reagents, bulk ancillary materials, and rare-target custom sourcing to accelerate your diagnostic assay development.