Rabbit anti-Human CD157/BST-1 mAb for FC - Q10588

Core Product Specifications and Parameters

Biological Background: CD157/BST-1 Function and Localization

• ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2, also known as CD157 or BST-1, catalyzes the synthesis of cyclic ADP-ribose (cADPR) from NAD+ and its hydrolysis to ADP-ribose (ADPR). cADPR is a second messenger that mobilizes intracellular calcium. Related references: PMID:7805847
• May be involved in pre-B-cell growth, suggesting a role in immune cell development.
• Localized to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor.
• Expressed in various tissues, including placenta, lung, liver, and kidney.
• Subject to alternative splicing, producing multiple isoforms.
• Post-translational modifications include glycosylation, a disulfide bond, and a GPI-anchor; the protein is a lipoprotein.

Experimental Guidance and Technical Tips

• The immunogen comprises a recombinant fusion protein spanning amino acids 29-292 of human CD157/BST-1, which corresponds to the extracellular domain; this design may support recognition of native cell surface antigen in flow cytometry.
• For flow cytometry, consider performing antibody titration to determine the optimal concentration, and use appropriate live-cell staining protocols with relevant isotype controls.
• Validate this antibody in a human cell line known to express CD157/BST-1, and confirm specificity by comparing staining profiles with appropriate negative controls or knockout models.
• If simultaneous detection of multiple markers is required, verify compatibility with your panel and compensation setup.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. For CD157/BST-1 research, CamelBio offers validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents to support diagnostic development and biomarker studies. Discover how our streamlined procurement model can accelerate your CD157/BST-1 projects.