Rabbit anti-Human CD138/Syndecan-1 Monoclonal Antibody for FC - P18827

Core Product Specifications and Parameters

Biological Background: Syndecan-1 Function and Localization

• Syndecan-1 (SDC1), also known as CD138, is a cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate chains, linking the cytoskeleton to the interstitial matrix.
• It regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). Related references: PMID:22660413
• Syndecan-1 is able to induce its own expression in dental mesenchymal cells and neighboring dental epithelial cells via an MSX1-mediated pathway.
• Subcellular localization includes the membrane, secreted forms, and presence in extracellular exosomes.
• Tissue specificity: detected at the protein level in placenta (PubMed:32337544) and in fibroblasts (PubMed:36213313). Related references: PMID:32337544 PMID:36213313
• Keywords from UniProt indicate it is a glycoprotein, phosphoprotein, and transmembrane proteoglycan with heparan sulfate modifications.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the extracellular domain (amino acids 23–251) of human CD138/Syndecan-1, suggesting the antibody likely recognizes the native cell surface protein.
• For flow cytometry (FC), consider using live, unfixed cells to preserve surface epitopes; titrate the antibody to determine the optimal working concentration and include appropriate isotype controls.
• Validate detection in human-derived cell systems known to express CD138, such as placental tissue or fibroblasts, as indicated by UniProt tissue specificity data.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers and research laboratories a one-stop sourcing platform for high-quality IVD raw materials. Our portfolio includes validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and support for rare-target raw material procurement. Whether your project focuses on oncology, exosome biology, or dental development, CamelBio streamlines access to essential tools like this CD138/Syndecan-1 antibody, helping accelerate your assay development from concept to clinic.