PTPRG Rabbit Polyclonal Antibody for WB and ELISA - P23470

Core Product Specifications and Parameters

Biological Background: PTPRG Function and Localization

• PTPRG is a receptor-type tyrosine-protein phosphatase that catalyzes the dephosphorylation of phosphotyrosine residues, regulating cellular signaling pathways.
• It is a transmembrane protein localized to the plasma membrane, where its extracellular domain may interact with ligands to modulate phosphatase activity.
• The protein undergoes alternative splicing, producing isoforms with potentially distinct functional properties.
• PTPRG is classified as a hydrolase and protein phosphatase, belonging to the receptor-type tyrosine phosphatase family.
• The full-length protein has a predicted molecular weight of approximately 162 kDa and is subject to post-translational modifications including glycosylation and phosphorylation.
• Expression of PTPRG is detected across a broad range of human tissues, suggesting general roles in cellular homeostasis.
• Structurally, it contains disulfide bonds essential for proper folding and extracellular domain stability.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 250-450 of human PTPRG, a region that may be conserved across species; cross-reactivity with mouse and rat has been observed in testing, but validation in your specific sample matrix is recommended.
• For Western blot, consider the predicted molecular weight of 162 kDa and optimize transfer and blocking conditions accordingly.
• This polyclonal antibody is suitable for ELISA; titrate the antibody to determine the optimal working concentration for your assay.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers, laboratories, and research institutes a streamlined sourcing solution for IVD raw materials. For receptor-type tyrosine-protein phosphatases like PTPRG, we provide reliable antibody pairs, optimized polyclonal antibodies, bulk ancillary reagents, and assistance in sourcing rare-target materials to support your assay development and research needs.