PPIH Rabbit pAb - O43447

Core Product Specifications and Parameters

Biological Background: PPIH Function and Localization

• PPIH encodes Peptidyl-prolyl cis-trans isomerase H, also known as Rotamase H, cyclophilin H (CypH), U-snRNP-associated cyclophilin SnuCyp-20, and USA-CYP.
• PPIase activity catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may assist protein folding. Related references: PMID:20676357
• Participates in pre-mRNA splicing and may act as a chaperone.
• Likely involved in the assembly of the U4/U5/U6 tri-snRNP complex, a critical component of the spliceosome.
• Subcellular localization includes nuclear speckles and the cytoplasm.
• Subject to acetylation and alternative splicing, producing multiple isoforms.
• Functional keywords: chaperone, isomerase, mRNA processing, mRNA splicing, rotamase, spliceosome.

Experimental Guidance and Technical Tips

• The immunogen is a recombinant fusion protein covering amino acids 1–177 of human PPIH (NP_006338.1). For optimal results, validate the antibody in your specific sample system.
• This polyclonal antibody is suitable for Western blot (WB) and ELISA. Consider using appropriate blocking and detection conditions based on your experimental setup.
• Since PPIH is conserved across human, mouse, and rat, you may use it for cross-species studies; verify specificity under your experimental conditions.
• For spliceosome-related research, evaluate the antibody in nuclear extracts or splicing-competent cell lines to capture functional states.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio streamlines IVD raw material procurement by providing a single source for validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and sourcing of rare targets. For splicing and chaperone research, this PPIH antibody is readily available alongside a comprehensive portfolio of related tools. Whether you require consistent lot-to-lot performance for diagnostic kit development or technical support during transition to clinic, our supply chain and consulting services cover every stage from concept to market.