PE/Cyanine7 Rabbit anti-Human CD56/NCAM1 Monoclonal Antibody for Flow Cytometry - P13591

Core Product Specifications and Parameters

Biological Background: CD56/NCAM1 Function and Localization

• Neural cell adhesion molecule 1 (NCAM1), also known as CD56, is a glycoprotein encoded by the NCAM1 gene in humans (GeneID: 4684).
• Plays a critical role in neuron-neuron adhesion, neurite fasciculation, and outgrowth of neurites, contributing to neural development and plasticity.
• Acts as a receptor for rabies virus and Zika virus, facilitating viral entry into host cells.
• Isoforms are generated by alternative splicing, resulting in various forms including secreted and GPI-anchored variants in addition to transmembrane proteins.
• Localizes primarily to the cell membrane, but soluble secreted isoforms are also produced.
• Post-translational modifications include N-linked glycosylation and phosphorylation, which may modulate its adhesion properties and signaling.

Experimental Guidance and Technical Tips

• This PE/Cyanine7-conjugated antibody is suitable for flow cytometry; titrate the antibody in your experimental system to determine optimal concentration and minimize background.
• Use appropriate isotype controls to distinguish specific staining from non-specific binding, especially when analyzing heterogeneous populations.
• Since the immunogen corresponds to amino acids 20–413 of human NCAM1, the antibody may recognize multiple isoforms, including secreted forms; validate in relevant human samples.
• CD56 is expressed on NK cells, subsets of T cells, and neural tissues; design your panel and gating strategy accordingly to accurately identify target populations.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, including this CD56/NCAM1 monoclonal antibody designed for flow cytometry applications. Our portfolio features validated antibody pairs, optimized monoclonals and polyclonals, bulk ancillary reagents, and custom sourcing for rare targets. Whether advancing neuroscience or virology research, CamelBio bridges your concept to clinic with reliable raw-material supply solutions.