PE/Cyanine7 Mouse anti-Human CD11c Monoclonal Antibody for FC - P20702

Core Product Specifications and Parameters

Biological Background: CD11c Function and Localization

• Integrin alpha-X (CD11c) is a type I transmembrane glycoprotein that pairs with the beta-2 (CD18) subunit to form the CD11c/CD18 integrin heterodimer.
• Functions as a receptor for fibrinogen, recognizing the G-P-R sequence, and mediates cell-cell adhesion during inflammatory responses.
• Critical for monocyte adhesion and chemotaxis, facilitating leukocyte trafficking to sites of inflammation.
• Serves as a receptor for the erythrocyte-specific adhesion molecule ICAM4 and mediates erythrophagocytosis. Related references: PMID:16985175
• Predominantly expressed on the cell membrane of monocytes and granulocytes.
• Contains extracellular calcium and magnesium binding sites, disulfide bonds, and FG-GAP repeat domains characteristic of integrin alpha subunits.
• Also known as CD11 antigen-like family member C, Leu M5, and leukocyte adhesion glycoprotein p150,95 alpha chain.
• The mature glycoprotein has an apparent molecular weight of approximately 128 kDa.

Experimental Guidance and Technical Tips

• The immunogen is full‑length recombinant human CD11c; the antibody may recognize all native isoforms of CD11c.
• Being directly conjugated with PE/Cyanine7, it is ready for single‑step flow cytometry; titrate to determine the optimal staining concentration for your specific cell type.
• Consider using human peripheral blood mononuclear cells (PBMCs) or isolated monocytes/granulocytes as positive controls.
• For functional blocking or cell‑adhesion assays, verify performance with your relevant experimental system and consider a carrier‑free formulation if required.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio simplifies procurement for diagnostic manufacturers, laboratories, and research institutes by providing consolidated access to IVD raw materials, technical support, and consulting services—from concept to clinic. This CD11c antibody is part of a broader portfolio addressing immunology and inflammation targets, with supply capabilities that include validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare‑target raw‑material sourcing. Whether you need conjugated formats, rapid delivery, or custom aliquoting, CamelBio connects you with the resources to advance your diagnostic development efficiently.