PE Rabbit anti-Mouse CD122/IL-2Rβ Monoclonal Antibody for Flow Cytometry - P16297

Core Product Specifications and Parameters

Biological Background: CD122/IL-2Rβ Function and Localization

• Interleukin-2 receptor subunit beta (CD122), also known as p70-75, is the beta chain of the high-affinity IL-2 receptor.
• Mediates receptor-mediated endocytosis upon IL-2 binding and transduces mitogenic signals essential for lymphocyte proliferation and activation.
• In association with IL-15 receptor alpha (IL-15RA), contributes to IL-15-induced neutrophil phagocytosis stimulation (By similarity).
• It is a single-pass type I transmembrane glycoprotein located on the cell surface and cell membrane.
• Contains a signal peptide, multiple disulfide bonds, and undergoes glycosylation, which are critical for its proper folding and function.
• Belongs to the type I cytokine receptor family and plays a central role in immune regulation and homeostasis.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the extracellular domain (amino acids 27-235), so the antibody likely recognizes the native conformation on live cells; for optimal flow cytometry staining, consider titrating the PE conjugate using relevant mouse lymphocyte populations.
• For applications beyond flow cytometry, validate the antibody in your specific experimental system, as performance may vary.
• When staining for CD122, be aware of co-expression with IL-15RA and potential internalization upon cytokine stimulation; process samples promptly after collection to maintain surface expression.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials. This PE anti-mouse CD122/IL-2Rβ monoclonal antibody supports immunology and cell signaling research, and through our integrated platform, we offer validated antibody pairs, bulk ancillary reagents, and custom sourcing of rare-target raw materials to accelerate your assay development and scale-up.