PE Rabbit anti-Human/Monkey CD10 mAb for FC - P08473

Core Product Specifications and Parameters

Biological Background: CD10 / Neprilysin Function and Localization

• Neprilysin is a zinc metalloprotease that cleaves peptide bonds on the amino side of hydrophobic residues, acting preferentially on polypeptides up to 30 amino acids. Related references: PMID:15283675, PMID:6208535, PMID:6349683
• Critically involved in the inactivation of opioid peptides such as Met- and Leu-enkephalins through Gly-Phe bond cleavage. Related references: PMID:17101991, PMID:6349683
• Catalyzes the proteolysis of vasoactive peptides including bradykinin, substance P, and neurotensin, modulating inflammatory and pain responses. Related references: PMID:6208535
• Processes angiotensin-1, angiotensin-2, and angiotensin 1-9, contributing to blood pressure regulation and cardiovascular homeostasis. Related references: PMID:15283675, PMID:6349683
• Degrades atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)), linking neprilysin activity to heart failure pathophysiology. Related references: PMID:16254193, PMID:2531377, PMID:2972276
• Exhibits UV-inducible elastase activity targeting skin preelastic and elastic fibers, suggesting a role in skin aging. Related references: PMID:20876573
• Located on the cell membrane as a type II integral membrane protein; disease variants are associated with Charcot-Marie-Tooth disease and spinocerebellar ataxia.

Experimental Guidance and Technical Tips

• The immunogen covers the entire extracellular domain (aa 52-750), so this antibody is expected to recognize the native surface epitope of CD10.
• As a PE-conjugated antibody, it is ready for direct flow cytometry without secondary amplification; consider titrating to determine the optimal working dilution.
• Cross-reactivity with cynomolgus monkey allows application in translational models; always validate performance in the specific sample system before use.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio streamlines IVD raw-material procurement for diagnostic and life science partners seeking CD10-related tools for oncology, cardiovascular, and neurology research. Beyond this PE anti-CD10 monoclonal antibody, we offer validated antibody pairs, bulk reagents, and custom sourcing of rare-target raw materials. Our integrated supply model helps you transition smoothly from concept to clinic with consistent, high-quality immunoreagents.