PE Rabbit anti-Human Neuropilin-2/NRP2 Monoclonal Antibody for FC - O60462

Core Product Specifications and Parameters

Biological Background: Neuropilin-2 Function and Localization

• Neuropilin-2 (NRP2), also known as vascular endothelial cell growth factor 165 receptor 2, is a multi-domain transmembrane receptor.
• It functions as a high-affinity receptor for class 3 semaphorins (Sema3C, Sema3F), VEGF-165, VEGF-145, and PLGF-2, playing roles in axon guidance, angiogenesis, and vascular development.
• NRP2 is involved in signal transduction that regulates cellular differentiation and developmental processes.
• The receptor also mediates human cytomegalovirus (HCMV) entry into epithelial and endothelial cells via the pentamer complex, highlighting its role in host-virus interactions.
• Subcellularly, NRP2 is found at the membrane and can also be secreted in a soluble form.
• Post-translational modifications include glycosylation and disulfide bond formation; it contains calcium-binding and heparin-binding domains.
• Alternative splicing produces multiple isoforms that may differ in function and localization.

Experimental Guidance and Technical Tips

• The immunogen encompasses the entire extracellular domain (aa 1-855), suggesting the antibody likely recognizes native NRP2 on the cell surface, ideal for flow cytometry.
• As a PE-conjugated monoclonal antibody, it eliminates the need for a secondary detection reagent; consider titrating the antibody to determine the optimal staining concentration for your specific cell type.
• Validate the antibody in relevant human cell lines known to express NRP2, and include appropriate isotype controls for accurate gating.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs with streamlined access to IVD raw materials, including validated antibody pairs, optimized monoclonal/polyclonal antibodies, and ancillary reagents. This anti-Neuropilin-2 antibody supports studies in vascular biology, oncology, and neurodevelopment. For projects requiring rare-target raw materials or comprehensive sourcing from concept to clinic, contact CamelBio for a tailored procurement solution.