PE Rabbit anti-Human Integrin β5/ITGB5 Monoclonal Antibody for FC - P18084

Core Product Specifications and Parameters

Biological Background: Integrin β5/ITGB5 Function and Localization

• Integrin beta-5 (ITGB5) is a subunit that pairs with integrin alpha-V to form the alpha-V/beta-5 integrin receptor.
• This receptor binds fibronectin by recognizing the RGD sequence in its ligand, mediating cell adhesion.
• It also acts as a receptor for adenovirus type C, facilitating viral entry into host cells.
• The protein localizes to the cell membrane as a single-pass type I membrane protein.
• Key structural features include EGF-like domains, multiple disulfide bonds, and extracellular calcium/magnesium-binding sites, characteristic of integrins.
• Post-translational modifications include N-linked glycosylation and phosphorylation; the protein belongs to the integrin family.
• The molecular weight is approximately 88 kDa.

Experimental Guidance and Technical Tips

• This antibody is directly conjugated to PE, suitable for flow cytometry without a secondary antibody.
• Validate antibody performance in the relevant sample system (e.g., human cells expressing ITGB5).
• Consider using appropriate isotype controls.
• For FC, follow standard staining protocols and avoid light exposure to preserve PE fluorescence.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, including validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents. This PE-conjugated anti-ITGB5 monoclonal antibody supports cell adhesion and viral entry research in flow cytometry applications. For rare target raw-material sourcing and comprehensive technical support from concept to clinic, CamelBio is your trusted partner.