PE Rabbit anti-Human CD42d/GPV mAb for FC - P40197

Core Product Specifications and Parameters

Biological Background: Platelet Glycoprotein V Function and Localization

• Platelet glycoprotein V (GPV, also known as CD42d) is a subunit of the GPIb-V-IX complex, which serves as the receptor for von Willebrand factor (vWF).
• The GPIb-V-IX complex mediates vWF-dependent platelet adhesion to blood vessels, a critical initiating event in hemostasis.
• GPV is specifically expressed in platelets and megakaryocytes.
• It is a transmembrane glycoprotein located on the platelet plasma membrane.
• Structurally, GPV contains leucine-rich repeats (LRRs), a signal peptide, and a transmembrane helix.
• It plays a key role in blood coagulation, cell adhesion, and hemostasis.
• The calculated molecular weight is approximately 60 kDa (60,959 Da).

Experimental Guidance and Technical Tips

• This antibody is supplied as a PE conjugate and is intended for flow cytometry (FC) applications.
• Consider validating the antibody in human platelet or megakaryocyte cell systems to confirm specificity and performance.
• For flow cytometry, include appropriate isotype controls and optimize titration to reduce nonspecific binding.

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