PE Rabbit anti-Human CD38 Monoclonal Antibody for FC - P28907

Core Product Specifications and Parameters

Biological Background: CD38 Function and Localization

• CD38 is a multifunctional transmembrane glycoprotein with both enzymatic and receptor activities.
• It synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion.
  Related references: PMID:7961800 PMID:8253715
• CD38 also produces nicotinate-adenine dinucleotide phosphate (NAADP+), a potent Ca2+ mobilizer, and exhibits cADPR hydrolase activity.
  Related references: PMID:16690024 PMID:7961800 PMID:8253715
• Acting as a receptor, it binds CD31 on endothelial cells to promote lymphocyte activation and transendothelial migration.
  Related references: PMID:9551996
• In dendritic cells, CD38 regulates CCL21-mediated migration, survival, and Th1 polarization.
  Related references: PMID:16293598
• In lamina propria T lymphocytes, CD38 signaling activates LCK and LAT, triggering cytokine release.
  Related references: PMID:11259373
• CD38 is localized at the cell surface and membrane, supporting its signaling functions.
• It is expressed in diverse tissues including pancreas, liver, kidney, brain, and lymphoid malignancies.

Experimental Guidance and Technical Tips

• For flow cytometry, titrate the PE-conjugated antibody to determine the optimal dilution in the relevant cell system. Include appropriate isotype controls and viability dyes.
• CD38 is expressed on various immune cells; consider using peripheral blood mononuclear cells (PBMCs) or lymphoma cell lines as positive controls.
• The immunogen covers the extracellular domain (aa 43-300), making this antibody suitable for detection of surface CD38 on live cells.
• Protect the PE conjugate from prolonged light exposure to maintain fluorophore stability.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your one-stop IVD raw-material sourcing partner, providing diagnostic manufacturers and research institutes with access to validated antibodies, reagents, and technical services from concept to clinic. This PE anti-CD38 monoclonal antibody supports flow cytometry-based CD38 detection in immunology and oncology research. We also supply bulk ancillary reagents and offer rare target raw-material sourcing to accelerate your assay development.