PE Rabbit anti-Human CD263/TRAIL-R3 Monoclonal Antibody for FC - O14798

Core Product Specifications and Parameters

Biological Background: CD263/TRAIL-R3 Function and Localization

• Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C), also known as Decoy Receptor 1 (DcR1), TRAIL-R3, CD263, LIT, and TRID.
• Functions as a receptor for the cytotoxic ligand TRAIL but lacks the intracellular death domain required to initiate apoptosis, thus acting as a decoy receptor.
• Protects cells from TRAIL-induced apoptosis by competing with the functional TRAIL receptors TNFRSF10A and TNFRSF10B for ligand binding.
• Localized to the cell membrane and anchored via a glycosylphosphatidylinositol (GPI) linkage.
• Higher expression in normal tissues compared to tumor cell lines; highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung, and heart.
• Contains disulfide bonds and is glycosylated; belongs to the TNF receptor superfamily characterized by cysteine-rich repeats.

Experimental Guidance and Technical Tips

• This antibody is supplied as a PE conjugate, allowing direct flow cytometry without the need for a secondary detection reagent.
• For optimal staining, titrate the antibody to determine the ideal concentration for your specific cell type and experimental conditions.
• As CD263/TRAIL-R3 is highly expressed in peripheral blood lymphocytes, these cells may serve as a suitable positive control for assay validation.
• Note that CD263/TRAIL-R3 is a GPI-anchored membrane protein; ensure that cell preparation and staining protocols preserve surface integrity.
• If using in combination with other antibodies, verify spectral compatibility of the PE fluorophore with your flow cytometer configuration.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your trusted partner for IVD raw-material sourcing, from early development to clinical application. We offer this PE-conjugated anti-CD263/TRAIL-R3 monoclonal antibody alongside a comprehensive portfolio of validated antibody pairs, optimized recombinant proteins, and bulk ancillary reagents for apoptosis and cancer research. Whether you need specialized monoclonals or rare target raw materials, our one-stop supply chain ensures reliable, high-quality products for diagnostic manufacturers and research laboratories.