PE Anti-Met/c-Met Monoclonal Antibody for Flow Cytometry - P08581

Core Product Specifications and Parameters

Biological Background: Hepatocyte Growth Factor Receptor (Met/c-Met) Function and Localization

• Encoded by the MET gene, the hepatocyte growth factor receptor (HGFR, c-Met) is a receptor tyrosine kinase that transduces signals upon binding its ligand HGF.
• It regulates key processes including proliferation, scattering, morphogenesis, and survival through downstream cascades like RAS-ERK, PI3K-AKT, and PLCγ-PKC.
• In embryonic development, MET is critical for gastrulation, neuronal precursor migration, angiogenesis, kidney formation, and skeletal muscle progenitor migration (By similarity).
• MET localizes to the membrane and can be secreted; it is widely expressed in epithelial cells of the liver, gastrointestinal tract, thyroid, kidney, and skin, with protein-level detection in bone (PubMed:26637977). Related references: PMID:26637977
• Acts as a receptor for Listeria monocytogenes internalin InlB, mediating bacterial entry.
• Post-translational modifications include phosphorylation, glycosylation, and ubiquitination, critical for signaling regulation.
• Also involved in adult wound healing, organ regeneration, and hematopoietic differentiation (By similarity).

Experimental Guidance and Technical Tips

• This PE-conjugated rabbit monoclonal antibody is intended for intracellular flow cytometry; careful optimization of fixation and permeabilization protocols is recommended.
• The immunogen covers the extracellular domain (aa 25–932) of human Met/c-Met, suggesting potential reactivity with both extracellular and intracellular epitopes; confirm surface staining compatibility if desired.
• Validate antibody specificity and optimal dilution in the relevant sample system, such as cultured human hepatocytes, epithelial cell lines, or tissue-derived single-cell suspensions.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a one-stop IVD raw-material partner, delivering validated antibodies and reagents to drive oncology and receptor research. This PE anti-Met/c-Met monoclonal antibody exemplifies our supply capability; we also offer comprehensive panels of matched antibody pairs, bulk ancillary reagents, and custom sourcing for rare targets. From concept to clinic, count on CamelBio to streamline your diagnostic development pipeline.