PDC Rabbit pAb - P20941

Core Product Specifications and Parameters

Biological Background: Phosducin (PDC) Function and Localization

• Phosducin (PDC), also known as MEKA or PhLP, is a 33 kDa phototransducing protein involved in the regulation of visual phototransduction.
• PDC modulates photoreceptor metabolism and inhibits the transcriptional activation activity of the cone-rod homeobox protein CRX.
• PDC is primarily expressed in photoreceptor cells, where it localizes to the outer and inner segments, as well as the connecting cilium.
• At the subcellular level, PDC is found in the cytoplasm and nucleus, consistent with its roles in signal transduction and transcription regulation.
• PDC undergoes alternative splicing, producing isoforms with potentially distinct functions.
• PDC is a phosphoprotein, suggesting regulation by phosphorylation in response to light/dark adaptation.
• Keywords include sensory transduction and vision, highlighting its critical role in the visual system.

Experimental Guidance and Technical Tips

• This antibody was raised against a recombinant protein encompassing the N-terminal 1-246 amino acids of human PDC. Confirm immunogen sequence alignment with your target species.
• Validated for Western blot (WB), immunohistochemistry-paraffin (IHC-P), and ELISA; optimize antibody dilutions for your specific assay and sample type.
• Predicted molecular weight of PDC is 28 kDa; use an appropriate gel percentage for detection in WB.
• Cross-reactivity with mouse and rat has been tested; verify conservation in other species if needed.
• For IHC-P, consider antigen retrieval methods and appropriate blocking to reduce background.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers comprehensive access to IVD raw materials, including this high-quality anti-PDC polyclonal antibody for visual transduction research. Beyond antibodies, we provide validated antibody pairs, optimized monoclonal/polyclonal reagents, and bulk ancillary supplies to support your diagnostic and research workflows. Whether you need rare-target reagents or large-scale manufacturing support, CamelBio streamlines your procurement process from concept to clinic.