NEUROG1 Rabbit pAb - Q92886

Core Product Specifications and Parameters

Biological Background: NEUROG1 Function and Localization

• NEUROG1 is a class A basic helix-loop-helix transcription factor, also known as neurogenin-1, NeuroD3, or bHLHa6.
• It functions as a transcriptional activator by binding to the E-box consensus sequence (5'-CANNTG-3') and associates with chromatin at enhancer regulatory elements of neurogenesis-related genes.
• NEUROG1 plays a critical role in the initiation of neuronal differentiation during development.
• It is exclusively expressed in the embryonic nervous system, underscoring its specificity for neurogenic precursor cells.
• The protein localizes to the nucleus, consistent with its role as a DNA-binding transcription factor.
• Human NEUROG1 gene variations are associated with diseases such as deafness and intellectual disability, highlighting its essential role in neural development.

Experimental Guidance and Technical Tips

• The immunogen spans the full-length human NEUROG1 protein (amino acids 1–237), which may contribute to broad recognition of the native protein.
• For Western blotting, the predicted molecular weight is ~26 kDa; consider using nuclear-enriched lysates to improve detection, given the nuclear localization of NEUROG1.
• The antibody has been validated for ELISA; consider optimizing coating conditions using recombinant NEUROG1 protein or nuclear extracts.
• Since cross-reactivity is reported for human and mouse, verify species-specific reactivity in your model system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic developers a streamlined path from discovery to clinical application, with a focus on high-quality IVD raw materials. This anti-NEUROG1 polyclonal antibody supports neurodevelopment and transcriptional regulation research, backed by our capability to supply validated antibody pairs, bulk ancillary reagents, and specialized raw materials for rare targets like neurogenic transcription factors. We serve as a comprehensive sourcing partner, helping you accelerate assay development with reliable, scalable solutions.