NAV2 Rabbit Polyclonal Antibody for WB, IHC-P, ELISA - Q8IVL1

Core Product Specifications and Parameters

Biological Background: NAV2 Function and Localization

• Possesses 3' to 5' helicase activity and exonuclease activity. Related references: PMID:12214280, PMID:15158073
• Involved in cytoskeleton organization. Related references: PMID:35218524
• Required for neurite outgrowth in response to stimulation by all-trans retinoic acid (atRA). Related references: PMID:18726912
• Important for brain and cerebellar development. Related references: PMID:35218524
• Involved in the development of the glossopharyngeal cranial nerve IX and the vagus cranial nerve X, possibly influencing neuronal cell elongation or survival and the baroreceptor reflex (By similarity).
• Localizes to the nucleus, cytoplasm, cytoskeleton, cell projection, axon, and perikaryon.
• Broadly expressed at low levels, with high expression in brain, kidney, liver, thyroid, mammary gland, spinal cord, heart, placenta, lung, and abundant expression in colon cancers. Related references: PMID:15158073
• Contains an ATP-binding site, coiled coil domain, and is subject to alternative splicing and phosphorylation; associated with a disease variant.

Experimental Guidance and Technical Tips

• Consider using positive control lysates from human brain, kidney, or liver tissues for Western blotting, given the high expression of NAV2 in these organs.
• For IHC-P, validate staining in neuronal tissues; note that NAV2 localizes to axons and the perikaryon.
• The antibody may detect multiple isoforms due to alternative splicing; confirm band sizes on your experimental system.
• Use pre-adsorption with the immunogen peptide as a negative control to verify specificity.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your one-stop partner for IVD raw-material sourcing, offering validated antibody pairs, optimized polyclonal and monoclonal antibodies, and bulk ancillary reagents to streamline diagnostic development. This NAV2 rabbit polyclonal antibody targets a key neuronal development protein, making it ideal for neuroscience research and diagnostic assay development. Leverage our expertise in rare target sourcing and comprehensive supply solutions from concept to clinic.