MYOZ2 Rabbit pAb for WB, IF/ICC, ELISA - Q9NPC6

Core Product Specifications and Parameters

Biological Background: Myozenin-2 Function and Localization

• Myozenin-2, also known as calsarcin-1 and FATZ-related protein 2, is encoded by the MYOZ2 (C4orf5) gene in humans.
• It serves as an intracellular binding protein that links Z-line proteins including alpha-actinin, gamma-filamin, TCAP/telethonin, and LDB3/ZASP at the sarcomere.
• Myozenin-2 plays a critical role in localizing calcineurin signaling to the sarcomere and contributes to myofibrillogenesis.
• The protein belongs to the myozenin family, which comprises several isoforms involved in sarcomeric organization.
• It is specifically expressed in heart and skeletal muscle tissues.
• Subcellularly, myozenin-2 localizes to the cytoplasm, myofibril, sarcomere, and Z line.
• Key biological keywords include involvement in cardiomyopathy and disease variants, and it undergoes phosphorylation and methylation.

Experimental Guidance and Technical Tips

• The immunogen covers amino acids 1-264 of human MYOZ2; consider validating specificity in KO/KD models if available.
• For Western blot (WB) of endogenous MYOZ2 in heart or skeletal muscle lysates, optimize loading amounts and antibody dilutions empirically.
• In immunofluorescence/ICC, include appropriate permeabilization and fixation steps to visualize Z-line localization.
• For ELISA applications, pair with a suitable secondary antibody and validate using known positive controls.
• Cross-reactivity with mouse and rat is expected; confirm expression and reactivity in the relevant tissue or cell lines.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive sourcing partner for IVD raw materials, connecting diagnostic manufacturers and research institutes with validated antibodies, bulk ancillary reagents, and rare-target procurement. The MYOZ2 Rabbit pAb supports investigations into sarcomere organization and cardiac/skeletal muscle biology, areas where reliable antibody supply is critical. Through its integrated technical services and supply chain, CamelBio helps streamline your development from concept to clinic.