MORF4L1 Rabbit Polyclonal Antibody for WB and ELISA - Q9UBU8

Core Product Specifications and Parameters

Biological Background: MORF4L1 Function and Localization

• MORF4L1 is a component of the NuA4 histone acetyltransferase complex, which acetylates histones H4 and H2A, promoting transcription and altering nucleosome-DNA interactions.
• The NuA4 complex is implicated in transcriptional programs related to oncogene-mediated growth, tumor suppression, senescence, apoptosis, and DNA repair.
• As part of the SIN3B complex, MORF4L1 represses transcription by counteracting EP300 activity via HDAC2 and recognizing H3K27ac marks. Related references: PMID:12391155, PMID:14966270, PMID:37137925
• MORF4L1 is recruited to active gene transcription start sites to modulate histone acetylation and RNA polymerase II progression, regulating transcription. Related references: PMID:21041482
• It is required for homologous recombination repair (HRR), resistance to mitomycin C, and facilitates localization of PALB2, BRCA2, and RAD51 to DNA damage foci.
• The protein localizes exclusively to the nucleus.
• It undergoes acetylation and alternative splicing, and functions as a chromatin regulator and transcription factor-like protein.

Experimental Guidance and Technical Tips

• This rabbit polyclonal antibody targets the N-terminal region (aa 1-100) of human MORF4L1; consider epitope accessibility and sample denaturation conditions for optimal results.
• For Western blot, an expected band at ~41 kDa should be detected in human, mouse, and rat cell lysates; optimize loading amounts and antibody dilution.
• For ELISA, validate the antibody with a proper antigen standard curve and consider a blocking step to reduce nonspecific binding.
• Validate species cross-reactivity in the appropriate sample system, as protein sequence homology may affect recognition.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive one-stop sourcing partner for IVD raw materials, connecting diagnostic manufacturers and laboratories with high-quality reagents. This anti-MORF4L1 polyclonal antibody is part of our portfolio tailored for chromatin biology and DNA repair research. Beyond individual antibodies, CamelBio supports your development with validated antibody pairs, bulk ancillary reagents, and sourcing of rare-target raw materials to accelerate your diagnostic pipeline.