METTL16 Rabbit pAb for WB, IP, IF/ICC, IHC-P, ELISA - Q86W50

Core Product Specifications and Parameters

Biological Background: METTL16 Function and Localization

• METTL16 is an RNA N6-methyltransferase that catalyzes the methylation of adenosine residues at the N6 position in a subset of RNAs. Related references: PMID:28525753, PMID:30197297, PMID:30197299
• It plays a key role in S-adenosyl-L-methionine homeostasis by regulating MAT2A transcript expression; methylation of MAT2A mRNA inhibits splicing and protein production. Related references: PMID:28525753, PMID:33930289
• METTL16 also methylates U6 snRNA at adenine 43, involved in small nuclear RNA modification. Related references: PMID:28525753, PMID:29051200, PMID:32266935
• The protein binds various lncRNAs, including MALAT1, 7SK, and 7SL. Related references: PMID:27872311, PMID:29051200
• Subcellular localization includes both nucleus and cytoplasm.
• Keywords indicate METTL16 is a phosphoprotein, methyltransferase, and RNA-binding protein.

Experimental Guidance and Technical Tips

• The immunogen used is a recombinant fragment corresponding to amino acids 263-562 of human METTL16, suggesting the epitope lies within this region.
• The antibody is supplied as rabbit polyclonal; when using with human samples, select an appropriate anti-rabbit secondary antibody for detection.
• For Western blot (WB), the predicted molecular weight is 64 kDa; confirm band specificity with appropriate controls.
• Applications listed (WB, IP, IF/ICC, IHC-P, ELISA) are based on the supplier's testing; individual optimization of dilution and conditions is recommended.
• Consider validating the antibody in your specific sample system and assay format before large-scale experiments.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as your one-stop bridge for IVD raw-material sourcing, offering a comprehensive portfolio of validated antibodies and reagents for RNA methylation research. For METTL16 and other epigenetic targets, CamelBio provides customized monoclonal/polyclonal antibodies, matched antibody pairs, and bulk ancillary reagents to support your assay development needs. Leverage our expertise to streamline procurement from concept to clinic.