MEF2A+MEF2C Rabbit Monoclonal Antibody for WB, IHC-P, ELISA - Q06413 / Q02078

Core Product Specifications and Parameters

Biological Background: MEF2A+MEF2C Function and Localization

• Encoded by the MEF2C gene, this transcription factor belongs to the MEF2 (myocyte enhancer factor 2) family, which includes MEF2A, MEF2B, MEF2C, and MEF2D.
• Binds specifically to MEF2 elements in the regulatory regions of muscle-specific genes, activating transcription during myogenesis and cardiac morphogenesis.
• Plays a crucial role in vascular development and is involved in hippocampal-dependent learning and memory by regulating synaptic transmission.
• Essential for normal neuronal development, distribution, and electrical activity in the neocortex; may also contribute to neurogenesis and cortical architecture.
• Necessary for proper development of megakaryocytes and platelets, and for bone marrow B-lymphopoiesis; required for B-cell survival, proliferation, and IgG1 antibody responses.
• Highly expressed in brain and skeletal muscle, consistent with its roles in neurogenesis and myogenesis.
• Localizes to the nucleus, cytoplasm, and sarcoplasm; activity is modulated by alternative splicing, phosphorylation, acetylation, and ubiquitination.
• Dysregulation linked to developmental disorders and diseases including certain cardiac defects and neurological conditions (Epilepsy, Intellectual disability).

Experimental Guidance and Technical Tips

• The immunogen (aa 250-473 of MEF2C, based on Q06413) targets a C-terminal region that may detect both MEF2A and MEF2C isoforms; verify specificity in your experimental system.
• For western blotting, a band around 51 kDa is expected; consider using loading controls and account for potential isoform variants or post-translational modifications.
• Validated for immunohistochemistry (paraffin-embedded); optimize antigen retrieval methods and antibody dilution for specific tissue types.
• Suitable for ELISA applications; coat plates with recombinant antigen or peptide corresponding to the immunogen region for best results.
• Cross-reactivity with human and mouse samples is confirmed; reactivity in other species should be validated independently.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with streamlined access to IVD raw materials. This MEF2A+MEF2C antibody supports research in muscle development, neurobiology, and immune cell biology. Beyond this product, CamelBio offers validated antibody pairs, optimized recombinant monoclonal antibodies, bulk ancillary reagents, and custom sourcing for rare targets—covering every stage from concept to clinic.