[KO Validated] Anti-SLC25A23 Polyclonal Antibody for WB, ELISA - Q9BV35

Core Product Specifications and Parameters

Biological Background: SLC25A23 Function and Localization

• SLC25A23 (also known as APC2, MCSC2, SCaMC-3) is a mitochondrial carrier protein that mediates electroneutral exchange of adenine nucleotides across the inner mitochondrial membrane.
  Related references: PMID:15123600

• It functions as an ATP-Mg/Pi carrier and a broad-specificity adenyl nucleotide antiporter, adapting the mitochondrial matrix adenine nucleotide pool to cellular energy demands.
  Related references: PMID:15123600

• SLC25A23 also regulates mitochondrial calcium uptake and can transport trace amounts of other divalent metal cations in complex with ATP.
  Related references: PMID:24430870, PMID:28695448

• In vitro, it shows low activity with guanyl and pyrimidine nucleotides.
  Related references: PMID:15123600

• The protein localizes exclusively to the mitochondrial inner membrane.

• Expression is ubiquitous but highest in brain, skeletal muscle, and pancreas.

• Keywords: alternative splicing, antiport, calcium, metal-binding, and transmembrane helix repeats.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (amino acids 1–160) of human SLC25A23. Consider using this antibody to detect a band at approximately 52 kDa in Western blotting of whole cell lysates or mitochondrial fractions.
• For ELISA, validate the antibody against the recombinant immunogen and native protein in relevant sample matrices.
• As the antibody exhibits cross-reactivity with mouse and rat SLC25A23, it may be suitable for studies in these species; confirm reactivity and specificity in your experimental system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research laboratories with one-stop access to validated IVD raw materials, including antibodies specific to mitochondrial carriers like SLC25A23. Our portfolio covers optimized polyclonal and monoclonal antibodies, antigen-grade recombinant proteins, and ancillary reagents for metabolism and calcium signaling research. For customized sourcing or technical consultation on rare targets, our team supports your project from concept to clinic.