[KO Validated] Anti-MTA2 Rabbit Monoclonal Antibody for WB, IHC-P, IF/ICC, ELISA, ChIP - O94776

Core Product Specifications and Parameters

Biological Background: MTA2 Function and Localization

• Metastasis-associated protein MTA2 (also known as MTA1-L1 or PID) is a component of the NuRD (nucleosome remodeling and deacetylase) complex, which participates in chromatin remodeling and acts as a transcriptional coregulator.
  Related references:
  PMID:16428440
  PMID:28977666
• The protein contains zinc-finger domains and exhibits DNA-binding and metal-binding properties.
• MTA2 is subject to multiple post-translational modifications, including acetylation, phosphorylation, and ubiquitination (Ubl conjugation), which may regulate its activity.
• Localized predominantly in the nucleus, MTA2 is widely expressed across tissues, consistent with a fundamental role in gene regulation.
• Alternative splicing of MTA2 yields multiple isoforms, potentially contributing to functional diversity.
• MTA2 is implicated in metastasis and cancer progression, making it a target of interest in oncology research.

Experimental Guidance and Technical Tips

• For Western blot, a specific band near 75 kDa is expected; validate in the relevant sample system.
• In immunoprecipitation-based assays like ChIP, optimize cross-linking and fragmentation conditions for successful enrichment.
• For immunofluorescence and immunohistochemistry, anticipate nuclear staining; co-stain with organelle markers to confirm localization.
• The antibody’s performance in ELISA may be assessed using the immunogen peptide as a positive control.
• Knockout validation (as indicated) provides additional confidence in specificity, but independent verification is recommended for critical experiments.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a one-stop sourcing partner for IVD raw materials, providing this anti-MTA2 rabbit monoclonal antibody for chromatin and cancer research applications. In addition to high-quality antibodies, CamelBio supplies validated antibody pairs, optimized bulk reagents, and rare-target sourcing services, supporting manufacturers from concept to clinic.