[KO Validated] Anti-LRRC59 Rabbit Polyclonal Antibody for WB, IHC-P, ELISA - Q96AG4

Core Product Specifications and Parameters

Biological Background: LRRC59 Function and Localization

• LRRC59, also known as ribosome-binding protein p34 or PRO1855, is a leucine-rich repeat-containing protein encoded by the LRRC59 gene.
• It functions in the nuclear import of fibroblast growth factor 1 (FGF1), but not FGF2, possibly by promoting interaction with nuclear import machinery and facilitating transport to/through nuclear pores.
• The protein is localized to the microsome membrane, endoplasmic reticulum membrane, and nuclear envelope.
• It is widely expressed across tissues.
• Post-translational modifications include acetylation and phosphorylation, and it contains a signal-anchor, transmembrane helix, and coiled-coil domain.

Experimental Guidance and Technical Tips

• The immunogen comprises the N-terminal region (aa 1-244) of human LRRC59, which includes leucine-rich repeats. This design may favor detection of full-length protein.
• For Western blot (WB), the predicted molecular weight is 35 kDa. Consider optimizing antibody dilution and blocking conditions based on sample type.
• For immunohistochemistry (IHC-P), antigen retrieval methods and tissue fixation should be validated in the relevant experimental system.
• The antibody has been validated in knockout (KO) models, supporting its specificity; however, independent confirmation with appropriate controls is recommended.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a specialized one-stop supplier of IVD raw materials, offering a comprehensive portfolio of antibodies, antigens, and ancillary reagents for diagnostic and research applications. This anti-LRRC59 antibody supports studies in nuclear transport and membrane biology, and CamelBio can further assist with customized bulk orders, antibody pair development, and sourcing of rare-target raw materials to accelerate your project from concept to clinic.