[KO Validated] Anti-Fascin/FSCN1 Rabbit Polyclonal Antibody for WB, IHC-P, IF/ICC, ELISA - Q16658

Core Product Specifications and Parameters

Biological Background: Fascin Function and Localization

• Fascin (FSCN1, also known as HSN, SNL, p55, FAN1) is a 55 kDa actin-bundling protein belonging to the fascin family.
• It contains two major actin-binding sites and organizes filamentous actin into parallel bundles, essential for the formation of filopodia and cell motility.
  Related references: PMID:21685497, PMID:23184945, PMID:20393565
• Fascin mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF.
  Related references: PMID:22155786
• Localizes to cytoplasm, cytosol, cell cortex, stress fibers, filopodia, invadopodia, microvilli, and cell junctions.
• Ubiquitously expressed in human tissues.
• Post-translational modifications include acetylation, phosphorylation, isopeptide bond formation, and ubiquitination.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the C-terminal region (aa 394-493) of human Fascin, designed to ensure specific recognition of the target.
• This antibody has been KO validated; consider using it for specificity controls in Fascin knockout experimental models.
• Recommended applications include WB, IHC-P, IF/ICC, and ELISA; optimal working dilutions should be determined empirically for each assay.
• The antibody cross-reacts with human, mouse, and rat Fascin; validate reactivity in your specific sample system if using other species.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research laboratories with streamlined access to high-quality IVD raw materials, technical services, and consulting support from concept to clinic. This anti-Fascin rabbit polyclonal antibody complements our expanding portfolio for actin cytoskeleton and cell motility research, where we also supply validated antibody pairs, bulk monoclonal/polyclonal antibodies, and ancillary reagents. For rare or custom target raw-material sourcing, our integrated supply chain can help accelerate your project development—contact us to discuss your requirements.