KD Validated Anti-MTMR3 Polyclonal Antibody for WB and ELISA - Q13615

Core Product Specifications and Parameters

Biological Background: MTMR3 Function and Localization

• MTMR3 is a phosphatase that specifically dephosphorylates phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) at the D-3 position. Related references: PMID:10733931, PMID:11302699, PMID:11676921
• By reducing PI3P levels, MTMR3 regulates cell signaling and intracellular membrane trafficking. Related references: PMID:11302699, PMID:11676921, PMID:12646134
• Besides its catalytic activity, MTMR3 may function as a molecular scaffold, regulating processes such as midbody abscission during cytokinesis. Related references: PMID:25659891
• The protein localizes to the cytoplasm, cytosol, and membrane regions.
• It belongs to the myotubularin family and contains a FYVE zinc finger domain, indicating membrane targeting.
• MTMR3 is involved in lipid metabolism and is a metal-binding phosphoprotein.
• Alternative splicing of the MTMR3 gene produces multiple transcript variants.

Experimental Guidance and Technical Tips

• The immunogen sequence (aa 640-810) is located near the C-terminus; this may facilitate recognition of full-length MTMR3 and alternatively spliced isoforms.
• For Western blot (WB), validate the antibody in a relevant human cell line or tissue lysate and consider using a loading control of similar molecular weight (~134 kDa).
• For ELISA applications, titrate the antibody and verify specificity with recombinant MTMR3 or known positive samples.
• As a polyclonal antibody, performance may vary between batches; establish optimal working dilutions empirically for each assay.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive sourcing partner for IVD raw materials, connecting diagnostic developers with validated antibodies, antigens, and ancillary reagents. This anti-MTMR3 polyclonal antibody addresses research needs in lipid signaling and cell cycle control. Whether you require custom antibody development, bulk procurement of this or related targets, or technical consultation from concept to clinic, CamelBio streamlines your supply chain with rigorous quality standards.