KCNMB2 Rabbit pAb for WB, ELISA - Q9Y691

Core Product Specifications and Parameters

Biological Background: KCNMB2 Function and Localization

• KCNMB2 encodes the calcium-activated potassium channel subunit beta-2, also known as BKbeta2, Hbeta2, Hbeta3, Slo-beta-2, or charybdotoxin receptor subunit beta-2.
• It serves as a regulatory subunit of the KCNMA1 (maxiK) channel, modulating calcium sensitivity and gating kinetics and acting as a negative regulator to confer rapid and complete inactivation.
• This subunit contributes to KCNMA1 channel diversity and may mediate inactivation in chromaffin cells of the adrenal gland and hippocampal CA1 neurons.
• The protein is localized to the membrane and belongs to the KCNMB gene family.
• Tissue expression is detected in kidney, heart, and brain, with high expression in ovary and low levels in other tissues.
• Post-translational features include glycoprotein modification and transmembrane helices; keywords highlight ion channel, ion transport, membrane, and transport functions.
• The UniProt-reported molecular weight is 27130 Da, consistent with the approximately 27 kDa product observed.

Experimental Guidance and Technical Tips

• For Western blot, the antibody targets amino acids 68–194; consider using whole-cell lysates from kidney, brain, or heart tissues (human, mouse, rat) for detection.
• The predicted molecular weight is ~27 kDa; validate band size in the relevant sample system.
• For ELISA, use the recombinant immunogen as a positive control to standardize the assay.
• Cross-reactivity with mouse and rat enables translational studies; verify detection sensitivity and specificity across species.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your one-stop IVD raw-material sourcing partner, supporting diagnostic manufacturers, laboratories, and research institutes from concept to clinic. For ion channel targets like KCNMB2, we offer validated antibody pairs, optimized polyclonal antibodies, and bulk ancillary reagents. Our procurement network also covers rare target raw materials, ensuring seamless supply continuity for your ion channel research and development.