KCNC1 Rabbit Polyclonal Antibody for WB, ELISA - P48547

Core Product Specifications and Parameters

Biological Background: KCNC1 Function and Localization

• KCNC1 encodes a voltage-gated potassium channel that opens upon membrane depolarization, allowing potassium efflux with slow inactivation kinetics (PubMed:25401298, PubMed:35840540). Related references: PMID:25401298, PMID:35840580
• It is essential for the rapid repolarization of fast-firing brain neurons, enabling sustained high-frequency action potential trains.
• The channel can form functional homotetrameric channels and heterotetrameric channels with KCNC2 and other family members, contributing to functional diversity.
• KCNC1 localizes to the cell membrane, axon, and presynaptic cell membrane, consistent with its role in neuronal signal propagation.
• Alternative splicing generates multiple isoforms, potentially expanding the functional repertoire of the channel.
• Mutations in KCNC1 are linked to epilepsy and neurodegenerative disorders (based on disease-associated keywords).
• The protein undergoes post-translational modifications, including glycosylation and phosphorylation, which may regulate channel trafficking and activity.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (amino acids 1–100) of human KCNC1; for Western blotting, verify band specificity using peptide competition or knockout control lysates.
• For WB, the predicted molecular weight is 58 kDa; use appropriate SDS-PAGE conditions and validate with a loading control.
• This antibody is applicable to ELISA; consider using it as a capture or detection reagent depending on the assay format, and include positive and negative controls to confirm performance.
• Cross-reactivity with mouse and rat KCNC1 has been observed, making it suitable for rodent neuroscience models; however, validate in the specific tissue or cell line of interest.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides a seamless sourcing experience for IVD raw materials, offering validated antibody pairs, optimized polyclonal and monoclonal antibodies, and bulk ancillary reagents. For neuroscience and ion channel research, this anti-KCNC1 antibody supports studies on neuronal excitability and related disorders. Partner with CamelBio to streamline your workflow from concept to clinic with reliable supply and expert support.