IGFBP5 Rabbit pAb - P24593

Core Product Specifications and Parameters

Biological Background: IGFBP5 Function and Localization

• Insulin-like growth factor-binding protein 5 (IGFBP5), also designated IBP5, is a secreted protein that modulates the bioavailability of insulin-like growth factors (IGFs).
• Regulates cell proliferation, differentiation, and apoptosis in a cell-type specific manner. Related references: PMID:18930415, PMID:7683690
• Acts as a major mediator of mTORC1-dependent negative feedback on IGF1 signaling.
• Promotes extracellular matrix (ECM) production and deposition independently of its IGF-binding activity. Related references: PMID:20345844, PMID:26103640
• Functions as an independent growth factor for bone formation, enhancing osteoblast proliferation.
• Serves as a ligand for the ROR1 receptor, triggering ROR1/HER2 heterodimerization and enhancing CREB oncogenic signaling. Related references: PMID:36949068
• Localized to the secreted compartment, cytoplasm, and nucleus; undergoes glycoprotein and phosphoprotein modifications.
• Highly expressed in osteosarcoma, with lower levels in liver, kidney, and brain.

Experimental Guidance and Technical Tips

• For Western blot, expect a band at approximately 31 kDa; validate using osteosarcoma or other positive control lysates.
• For IHC-P and IF/ICC, optimize antigen retrieval conditions and consider known positive tissues (e.g., osteosarcoma, liver).
• For ELISA applications, test antibody pairing compatibility with your assay format.
• The immunogen (aa 68–167) may detect full-length and certain processed forms; confirm reactivity in your sample system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your dedicated partner for IVD raw-material sourcing, offering validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and custom rare-target procurement. This IGFBP5 Rabbit Polyclonal Antibody supports research into growth factor signaling, oncology, and bone biology, making it a strong candidate for diagnostic assay development. From concept to clinic, CamelBio provides the supply-chain reliability and technical consultation you need.