HMG20B Rabbit pAb for WB, ELISA - Q9P0W2

Core Product Specifications and Parameters

Biological Background: HMG20B Function and Localization

• Required for correct progression through G2 phase of the cell cycle and entry into mitosis.
• Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.
• Localizes to the nucleus and chromosome.
• Ubiquitously expressed in adult tissues.
• Contains an HMG box DNA-binding domain and functions as a chromatin regulator.
• Involved in transcription regulation and chromatin remodeling.
• Post-translational modifications include phosphorylation and ubiquitination (isopeptide bond).
• Alternative splicing produces multiple isoforms.

Experimental Guidance and Technical Tips

• Validate antibody performance in your sample system (e.g., human, mouse) using the recommended applications.
• For WB, consider a starting antibody dilution range and optimize based on signal-to-noise ratio; a band near 36 kDa is expected.
• For ELISA, pair this antibody with appropriate capture/detection antibodies if used in a sandwich format.
• Confirm cross-reactivity in mouse tissues experimentally, as sequence homology may influence detection sensitivity.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials. This HMG20B-targeting antibody supports research into chromatin regulation, cell cycle progression, and transcription repression. We offer validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare target raw-material sourcing to streamline your diagnostic development from concept to clinic.