HABP2 Rabbit pAb for WB, IF/ICC, ELISA - Q14520

Core Product Specifications and Parameters

Biological Background: HABP2 Function and Localization

• HABP2 (Hyaluronan-binding protein 2) encodes a secreted serine protease, also referred to as Factor VII-activating protease, FSAP, PHBP, and HGFAL.
• The protease cleaves fibrinogen alpha- and beta-chains without initiating fibrin clot formation or direct fibrinolysis, but it activates pro-urokinase (single-chain urinary plasminogen activator) into its active two-chain form. Related references: PMID:11217080 PMID:10754382
• It activates coagulation factor VII (Probable).
• May act as a tumor suppressor by inhibiting cell proliferation and migration. Related references: PMID:26222560
• Secreted into the extracellular space.
• Expressed ubiquitously in human tissues.
• Structurally, the protein features an N-terminal signal peptide, multiple EGF-like and kringle domains, and a C-terminal serine protease domain; it is glycosylated and contains disulfide bonds.

Experimental Guidance and Technical Tips

• The immunogen spans the N-terminal portion (amino acids 24–313), providing multiple epitopes; this polyclonal antibody is well-suited for WB and ELISA.
• For WB, expect a band near 63 kDa (precursor), but proteolytic processing may generate additional bands depending on the sample’s activation state—validate in your specific experimental system.
• In IF/ICC, permeabilization may be required since the target is secreted; consider co-staining with extracellular markers to confirm localization.
• As a polyclonal reagent, verify lot-to-lot consistency for critical quantitative applications.

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