GLUT3/SLC2A3 Rabbit pAb - P11169

Core Product Specifications and Parameters

Biological Background: GLUT3/SLC2A3 Function and Localization

• GLUT3/SLC2A3 mediates facilitative glucose uptake and transport of galactose, mannose, xylose, and fucose, but not fructose. Related references: PMID:26176916, PMID:9477959
• It likely also transports dehydroascorbate. Related references: PMID:26176916, PMID:9477959
• Required for mesendoderm differentiation (By similarity).
• Localizes to the cell membrane, perikaryon, and cell projections.
• Highly expressed in brain and expressed in many tissues. Related references: PMID:8457197
• Post-translationally modified as a glycoprotein and phosphoprotein.
• Contains 12 transmembrane helices and has a molecular weight of approximately 54 kDa.
• Part of the sugar transport SLC2 family with available 3D structures.

Experimental Guidance and Technical Tips

• Given the immunogen is a fragment from the central region (amino acids 207-281), this antibody may recognize an epitope conserved in human, mouse, and rat, aligning with the listed cross-reactivity. Sequence alignment is recommended when testing on other species.
• For western blotting, expect a band around 54 kDa; use brain tissue lysates as a positive control and validate with appropriate loading controls.
• For IHC-P, consider antigen retrieval optimization, as GLUT3 is a multi-pass transmembrane protein; test citrate or EDTA-based retrieval buffers.
• When developing ELISA assays, validate this antibody as a capture or detection reagent after checking paired antibody compatibility.

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