GAS2 Rabbit Polyclonal Antibody for WB, IHC-P, ELISA - O43903

Core Product Specifications and Parameters

Biological Background: Growth arrest-specific protein 2 (GAS2) Function and Localization

• Growth arrest-specific protein 2 (GAS2, also known as GAS-2) is encoded by the GAS2 gene in humans.
• It is required to maintain microtubule bundles in inner ear supporting cells, providing mechanical stiffness essential for sound energy transmission through the cochlea.
• Alternative splicing generates multiple isoforms of GAS2.
• The protein localizes to the cytoplasm, cytoskeleton (particularly stress fibers), and membrane.
• Classified as a phosphoprotein, GAS2 is implicated in apoptosis, cell cycle regulation, cell shape maintenance, and growth arrest.
• Mutations in GAS2 are associated with non-syndromic deafness.
• GAS2 is ubiquitously expressed, with highest levels in liver, lung, and kidney, but is not found in the spleen.

Experimental Guidance and Technical Tips

• The immunogen covers the N-terminal 1–100 amino acids of human GAS2, making it suitable for detecting full-length and likely N-terminal‑containing isoforms.
• For Western blot (WB), the predicted molecular weight is approximately 35 kDa; consider validating in lysates from liver or lung, where GAS2 is highly expressed.
• When performing immunohistochemistry (IHC-P), optimize antigen retrieval and antibody dilution on sections of liver, lung, or kidney tissue.
• As a polyclonal antibody, it may detect multiple isoforms; confirm specificity using knockdown or knockout controls where necessary.
• Confirmed cross-reactivity with mouse supports its use in mouse models for inner ear biology or cell cycle studies.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a dedicated one‑stop sourcing partner, offering diagnostic manufacturers and research laboratories streamlined access to high‑quality IVD raw materials such as this GAS2 antibody. Whether you require validated antibody pairs, optimized polyclonal antibodies, or bulk ancillary reagents, we bridge gaps from concept to clinic. Tell us your target—let us handle the sourcing so you can focus on advancing inner ear and cell cycle research.