FOXG1 Rabbit pAb - P55316

Core Product Specifications and Parameters

Biological Background: FOXG1 Function and Localization

• FOXG1, also known as Brain factor 1 (BF-1) or Forkhead box protein G1, is a member of the forkhead box (FOX) family of transcription factors.
• It functions as a transcription repression factor crucial for the establishment of the regional subdivision of the developing brain, particularly in telencephalon development.
• The protein is predominantly localized in the nucleus, where it binds DNA to regulate gene expression.
• Its expression is highly restricted to neurons of the developing telencephalon, highlighting its specialized role in neurodevelopment.
• Mutations in FOXG1 are associated with disease variants, including intellectual disability and Rett syndrome-like phenotypes.
• The protein has a calculated molecular weight of approximately 52 kDa and includes multiple isoforms such as FOXG1A, FOXG1B, and FOXG1C.

Experimental Guidance and Technical Tips

• For Western blot, consider using an appropriate gel percentage to resolve the 52 kDa band, and validate the antibody in your specific tissue or cell lysate.
• Given the peptide immunogen (aa 400-489), this antibody may be suitable for peptide-based ELISA applications; optimize assay conditions for your sample matrix.
• Cross-reactivity is reported for human, mouse, and rat; verify performance in your experimental system to account for potential interspecies variations.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as your comprehensive sourcing partner for IVD raw materials, providing reliable access to validated antibodies like FOXG1 Rabbit pAb for neurodevelopmental research. We also supply optimized antibody pairs, bulk ancillary reagents, and can assist in sourcing rare-target raw materials to accelerate your diagnostic development from concept to clinic.