FKBP1B Rabbit pAb - P68106

Core Product Specifications and Parameters

Biological Background: FKBP1B Function and Localization

• FKBP1B is a peptidyl-prolyl cis-trans isomerase (PPIase) also known as 12.6 kDa FK506-binding protein, FKBP12.6, or Immunophilin FKBP12.6.
• It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides, accelerating protein folding.
• FKBP1B binds the immunosuppressive drugs FK506 and rapamycin, potentially mediating their toxic effects.
• The protein is localized in the cytoplasm and sarcoplasmic reticulum.
• It is detected in heart muscle at the protein level; its isoforms are ubiquitous with highest expression in brain and thymus.
• Keywords include alternative splicing and rotamase activity.

Experimental Guidance and Technical Tips

• The immunogen is designed against the N-terminal region (amino acids 1-80) common to FKBP1B isoforms, ensuring broad detection.
• For Western blotting, the predicted molecular weight is ~12 kDa; optimize gel percentage and transfer conditions for low molecular weight proteins.
• In immunofluorescence/ICC, anticipate cytoplasmic and sarcoplasmic reticulum staining; co-stain with appropriate markers for validation.
• Validate the antibody in relevant sample systems (e.g., heart, brain, thymus) where FKBP1B is highly expressed.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides a comprehensive range of IVD raw materials, including validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents, supporting your research from concept to clinic. For studies focusing on immunophilin biology and FK506-related pathways, this FKBP1B antibody is part of our portfolio designed to accelerate diagnostic development.