ELAPOR1 Rabbit pAb - Q6UXG2

Core Product Specifications and Parameters

Biological Background: ELAPOR1 Function and Localization

• ELAPOR1, also known as EIG121 or KIAA1324, is a transmembrane glycoprotein with a predicted molecular weight of ~111 kDa; it undergoes alternative splicing.
• Functions to protect cells from death by inducing cytosolic vacuolization and upregulating the autophagy pathway. Related references: PMID:21072319
• May regulate apoptosis and cell proliferation through interaction with the endoplasmic reticulum chaperone HSPA5. Related references: PMID:26045166
• Localizes to multiple membrane compartments including the cell membrane, late endosomes, lysosomes, trans-Golgi network, and endoplasmic reticulum.
• Contains a signal peptide, multiple transmembrane helices, and disulfide bonds; annotated with proteomics identification.
• Tissue expression: detected in normal endometrium but often overexpressed in endometroid tumors, implicating it in gynecological cancers.

Experimental Guidance and Technical Tips

• The immunogen covers amino acids 30–130 of human ELAPOR1, a region likely present in multiple isoforms; confirm the epitope in your target sample.
• For Western blotting, prepare whole-cell lysates or membrane-enriched fractions, as ELAPOR1 localizes to endomembranes; the predicted molecular weight is 111 kDa.
• Cross-reactivity with mouse and rat suggests epitope conservation; validation in these species is recommended if used for non-human models.
• ELISA protocols may use recombinant protein or peptide coating; optimize antibody concentration empirically.
• Since ELAPOR1 is overexpressed in certain tumors, consider using relevant cancer cell lines or tissue lysates for positive controls.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your trusted one-stop sourcing partner for IVD raw materials, offering validated antibodies, recombinant proteins, and ancillary reagents. This ELAPOR1 Rabbit pAb supports apoptosis, autophagy, and cancer research, and we can supply optimized antibody pairs and bulk material for diagnostic development. Our technical team assists with raw-material selection and assay design to accelerate your project from concept to clinic.