DNAJC17 Rabbit pAb - Q9NVM6

Core Product Specifications and Parameters

Biological Background: DNAJC17 Function and Localization

• DNAJC17 is a member of the DnaJ/Hsp40 chaperone family, characterized by a conserved J-domain that assists in protein folding and quality control.
• It functions as a transcriptional coregulator, negatively affecting PAX8-induced thyroglobulin (TG) transcription.
• Subcellular localization includes both cytoplasm and nucleus, enabling participation in nuclear transcriptional regulation and cytoplasmic chaperone activities.
• Post‑translational modifications include phosphorylation and methylation, which may modulate its activity and interactions.
• Exhibits RNA‑binding activity, suggesting roles in RNA metabolism or translational control.
• Keywords encompass chaperone, transcription regulation, and RNA‑binding, indicating a multifunctional protein.

Experimental Guidance and Technical Tips

• The immunogen covers the full‑length protein (amino acids 1‑304), ensuring recognition of the native DNAJC17 in relevant species.
• For Western blot, an ~35 kDa band is expected; optimize antibody dilution based on sample type.
• IHC‑P may require standard antigen retrieval methods; validate staining in positive control tissues.
• ELISA can be used for quantification; consider pairing with suitable capture/detection systems.
• Cross‑reactivity with mouse and rat suggests conserved epitopes; confirm performance in your model system.

CamelBio: Your One‑Stop Sourcing Bridge

CamelBio serves as a comprehensive partner for IVD raw material sourcing, delivering validated antibodies like this anti‑DNAJC17 rabbit pAb to accelerate your research into transcriptional regulation and chaperone biology. Beyond this product, we offer optimized monoclonal/polyclonal antibody pairs, bulk ancillary reagents, and custom sourcing for rare‑target raw materials, ensuring a seamless supply chain from discovery to diagnostic development.