Destrin Rabbit Monoclonal Antibody for WB and ELISA - P60981

Core Product Specifications and Parameters

Biological Background: Destrin Function and Localization

• Destrin, also known as actin-depolymerizing factor (ADF), is encoded by the DSTN gene.
• It functions as an actin-binding protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin), promoting actin depolymerization.
• This depolymerizing activity is pH-independent, distinguishing it from some other ADF/cofilin family members.
• According to UniProt, destrin is widely distributed in various tissues.
• Post-translational modifications include acetylation, phosphorylation, and ubiquitin-like (Ubl) conjugation, as derived from curated keywords.
• The protein has been identified through proteomics and direct protein sequencing.

Experimental Guidance and Technical Tips

• The antibody was raised against a synthetic peptide corresponding to amino acids 1–100 of human destrin; consider epitope accessibility in your assay design.
• For western blotting, the predicted molecular weight is 19 kDa; use appropriate gel percentage and transfer conditions for low-molecular-weight proteins.
• Cross-reactivity with human, mouse, and rat is reported; validate detection in the relevant sample system.
• For ELISA, optimize coating antigen concentration and antibody dilution to achieve desired sensitivity.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. This anti-Destrin monoclonal antibody is suitable for research into actin dynamics and cytoskeleton regulation. For your specific assay development needs, CamelBio offers validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and rare target raw-material sourcing.