COQ9 Rabbit pAb - O75208

Core Product Specifications and Parameters

Biological Background: COQ9 Function and Localization

• COQ9 is a mitochondrial membrane-associated protein that facilitates coenzyme Q (ubiquinone) biosynthesis by binding ubiquinone intermediates and presenting them to COQ7 for hydroxylation. Related references: PMID:25339443 PMID:30661980 PMID:38425362
• Coenzyme Q is an essential lipid-soluble electron transporter required for aerobic cellular respiration. Related references: PMID:25339443 PMID:30661980
• COQ9 is predominantly localized to the mitochondria, consistent with its role in ubiquinone biosynthesis.
• Post-translational modifications of COQ9 include acetylation and ubiquitin conjugation, which may regulate its activity or stability.
• Alternative splicing of the COQ9 gene may produce multiple protein isoforms, as indicated by proteomics evidence.
• Mutations in COQ9 are associated with primary mitochondrial disease, highlighting its critical role in CoQ10 synthesis and mitochondrial health.

Experimental Guidance and Technical Tips

• The immunogen is a recombinant full-length sequence (aa 1–318), suggesting the antibody may detect multiple epitopes. For Western blot, a specific band around 36 kDa is expected; consider using knockout or knockdown controls to confirm specificity.
• The antibody is suitable for ELISA; optimal coating concentration and detection conditions should be experimentally determined for each assay format.
• For best results, validate the antibody in your specific sample type and optimize detection parameters.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with a comprehensive portfolio of IVD raw materials, including validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents. This COQ9 antibody supports research in mitochondrial biology and coenzyme Q metabolism. Our sourcing capabilities extend to rare targets, ensuring reliable supply tailored to your development needs.