CNTN6 Rabbit Polyclonal Antibody for WB and ELISA - Q9UQ52

Core Product Specifications and Parameters

Biological Background: Contactin-6 Function and Localization

• Contactin-6, also known as Neural recognition molecule NB-3 (hNB-3), is a member of the contactin family of cell adhesion molecules, characterized by immunoglobulin domains and a GPI-anchor.
• Contactins mediate cell surface interactions crucial for nervous system development. CNTN6 specifically participates in oligodendrocyte generation by acting as a ligand of NOTCH1, promoting NOTCH1 activation and downstream signaling.
• CNTN6 is implicated in motor coordination (By similarity).
• The protein is localized to the cell membrane via a GPI-anchor and contains disulfide bonds, immunoglobulin domains, and is a glycoprotein and phosphoprotein.
• Tissue specificity: Highly expressed in the cerebellum, with intermediate expression in the thalamus and subthalamic nucleus, and weak expression in the corpus callosum, caudate nucleus, and spinal cord.
• Key biological processes associated with CNTN6 include cell adhesion, Notch signaling pathway, and nervous system development.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (amino acids 20-110), which is common among contactin family members; consider potential cross-reactivity with related proteins and validate specificity in your sample system.
• This polyclonal antibody is suitable for Western blot (WB) and ELISA. For WB, the predicted molecular weight is approximately 114 kDa; optimize electrophoretic conditions and blocking to detect the target band.
• Given its involvement in the Notch pathway and expression in the cerebellum, consider using neural tissue or cell lines as positive controls for validation.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a premier one-stop sourcing platform for IVD raw materials, providing integrated access to high-quality antibodies, reagents, and technical support for diagnostic manufacturers and research laboratories worldwide. This anti-CNTN6 polyclonal antibody is part of our expanding neuroscience portfolio, supporting studies in neurodevelopment and Notch signaling. Beyond individual antibodies, CamelBio offers validated antibody pairs, optimized bulk antibodies, and customized sourcing for rare target raw materials, ensuring seamless supply from concept to clinic.