CD267/TACI Rabbit Monoclonal Antibody for Flow Cytometry - Q9ET35

Core Product Specifications and Parameters

Biological Background: CD267/TACI Function and Localization

• Tumor necrosis factor receptor superfamily member 13B (TNFRSF13B), also known as Transmembrane activator and CAML interactor (TACI), is encoded by the Tnfrsf13b gene in mice.
• Functions as a high-affinity receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS, mediating calcineurin-dependent NF-AT activation and NF-kappa-B and AP-1 pathways.
• Plays a critical role in the stimulation of B- and T-cell function and the regulation of humoral immunity.
• Localized to the cell membrane with a single-pass transmembrane domain and signal-anchor.
• Contains disulfide bond-rich repeat regions characteristic of the TNF receptor superfamily.
• Key keywords: Adaptive immunity, Immunity, Receptor, Transmembrane, Membrane, Reference proteome.

Experimental Guidance and Technical Tips

• The immunogen covers the N-terminal extracellular region (amino acids 5-129), suggesting recognition of an epitope accessible on the cell surface, making it suitable for native surface staining.
• For flow cytometry, consider using mouse splenocytes or B-cell lines; validate staining with an appropriate isotype control and titrate the antibody to optimize signal-to-noise ratio.
• Since TACI is expressed on mature B cells and activated T cells, confirm expression patterns in your specific sample system before use.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio acts as a comprehensive sourcing partner for IVD raw materials, supplying validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents to support immunology and B-cell research. For diagnostic manufacturers and labs working with rare targets like TACI, CamelBio’s supply chain capabilities help bridge the gap from concept to clinic, ensuring timely access to critical reagents.