CD200 Rabbit pAb for WB, ELISA - P41217

Core Product Specifications and Parameters

Biological Background: CD200 Function and Localization

• CD200 (OX-2 membrane glycoprotein) is encoded by the CD200 gene (also known as MOX1, MOX2) and belongs to the immunoglobulin superfamily of cell surface glycoproteins.
• It functions as a costimulatory molecule that enhances T-cell proliferation upon interaction with its receptor.
• CD200 may regulate myeloid cell activity across various tissues, contributing to immune homeostasis and modulation.
• The protein is localized to the cell membrane, consistent with its role in mediating cell–cell communication and signaling.
• It contains an immunoglobulin-like domain and is characterized by post-translational modifications such as glycosylation and disulfide bond formation.
• Alternative splicing generates multiple isoforms of CD200, potentially with distinct functional roles.

Experimental Guidance and Technical Tips

• The immunogen covers the extracellular domain (amino acids 30–240), suggesting the antibody may recognize native, membrane-bound CD200 in immunodetection applications.
• For Western blot, consider using reducing conditions and appropriate loading controls due to the protein’s glycoprotein nature and potential for dimerization.
• In ELISA, the antibody can potentially serve as a capture or detection reagent for CD200 in cell lysates or serum, with optimization of coating and blocking steps.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs with one-stop access to IVD raw materials, including this CD200 antibody for immunology research and assay development. Our portfolio encompasses validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents, supporting your diagnostic pipeline from concept to clinic.