CD138 Rabbit mAb - P18827

Core Product Specifications and Parameters

Biological Background: CD138/Syndecan-1 Function and Localization

• CD138, also known as Syndecan-1, is a cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate chains.
• It functions as a linker between the cytoskeleton and the interstitial matrix (By similarity).
• It regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). Related references: PMID:22660413
• It is detected in placenta (PubMed:32337544) and in fibroblasts (PubMed:36213313). Related references: PMID:32337544 PMID:36213313
• Localizes to the membrane, secreted, and in extracellular exosomes.
• Post-translationally modified by addition of heparan sulfate and chondroitin sulfate; classified as a glycoprotein and proteoglycan.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the extracellular domain (aa 23-251), suggesting the antibody recognizes the ectodomain of CD138.
• For IHC-P, consider using heat-induced antigen retrieval in citrate or EDTA buffer; validate staining in known CD138-positive tissues (e.g., plasma cells).
• For flow cytometry, use appropriate cell permeabilization if detecting intracellular epitopes; surface staining may require live unfixed cells.
• In ELISA, the antibody may be used for capture or detection with recombinant CD138 protein; titration is recommended.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a dedicated IVD raw material supplier offering one-stop access to validated antibodies, bulk reagents, and technical support. This CD138 monoclonal antibody is part of our extensive catalog tailored for diagnostic manufacturers and researchers focusing on plasma cell disorders and oncology. Leverage our sourcing expertise to accelerate your assay development from concept to clinic.