AVEN Rabbit Polyclonal Antibody for WB, ELISA - Q9NQS1

Core Product Specifications and Parameters

Biological Background: AVEN Function and Localization

• AVEN (Cell death regulator Aven) protects against apoptosis mediated by Apaf-1, as documented in UniProtKB.
• It functions as an inhibitor of apoptosome-mediated caspase activation, highlighting its role in cell death regulation.
• The protein is associated with the endomembrane system, indicating a membrane-related subcellular localization.
• Highly expressed across multiple tissues including testis, ovary, thymus, prostate, spleen, small intestine, colon, heart, skeletal muscle, liver, kidney, and pancreas, suggesting diverse roles in apoptosis control.
• Post-translational modifications likely include phosphorylation and methylation, as annotated by UniProtKB keywords.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the central region (aa 203–362) of human AVEN; expect reactivity with full-length endogenous protein.
• For Western blot, a main band at approximately 39 kDa should be observed; validate with positive control lysates from tissues with high expression such as testis or ovary.
• Cross-reactivity has been confirmed for human and rat; for other species, sequence homology alignment is recommended before use.
• In ELISA, consider titrating the antibody and using appropriate blocking to minimize non-specific binding.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with one-stop access to IVD raw materials and sourcing solutions. This AVEN polyclonal antibody supports research into apoptosis and cell death pathways, and our platform offers additional validated antibody pairs, optimized monoclonals, and bulk ancillary reagents for IVD development. From custom antibody generation to rare-target raw material sourcing, CamelBio streamlines the path from concept to clinic with reliable procurement support.