ARR3 Rabbit pAb for WB, ELISA - P36575

Core Product Specifications and Parameters

Biological Background: ARR3 Function and Localization

• ARR3 encodes cone arrestin (cArr), a member of the arrestin family specifically expressed in retinal cone photoreceptors.
• Allegedly has a role in retina-specific signal transduction, potentially binding photoactivated-phosphorylated red/green opsins.
• Located primarily in photoreceptor inner and outer segments and the cilium of cone cells.
• Tissue expression restricted to retinal inner and outer segments and inner plexiform regions.
• Keywords indicate involvement in sensory transduction and vision, with alternative splicing and disease variants noted.
• Molecular weight of the native protein is ~43 kDa (UniProt: 42778 Da), consistent with the calculated 43kDa of the immunogen.
• The protein contains disulfide bonds, relevant for structural stability; proteomic identification supports its retina-specific role.

Experimental Guidance and Technical Tips

• The immunogen spans the N-terminal region (aa 1-260), providing a robust target for antibody generation.
• For Western blot, expect a band near 43 kDa; validate in retinal tissue lysates or appropriate cell lines.
• ELISA can be used for quantitative assays; consider using recombinant ARR3 protein as a standard.
• Cross-reactivity with mouse and rat allows testing in rodent models of retinal function.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a comprehensive IVD raw-material sourcing platform, supplying validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents. This ARR3 polyclonal antibody supports research in retinal signal transduction and vision-related diagnostics. Leverage our one-stop supply chain to accelerate your assay development with reliable, high-quality raw materials.