Arginase 2 (ARG2) Rabbit pAb for WB, ELISA - P78540

Core Product Specifications and Parameters

Biological Background: Arginase-2 Function and Localization

• Arginase-2 (ARG2) is a mitochondrial enzyme that hydrolyzes L-arginine to urea and L-ornithine, functioning in extra-urea cycle arginine metabolism.
• It regulates nitric oxide (NO) synthesis by competing with nitric oxide synthase (NOS) for the substrate L-arginine, thereby down-regulating NO production.
• ARG2 is distinct from the hepatic isoform arginase-1 and is broadly expressed in extrahepatic tissues including kidney, prostate, brain, and immune cells.
• The protein localizes to the mitochondrion, participating in polyamine and proline biosynthesis linked to cellular metabolism and immune regulation.
• Key immune roles include negative regulation of activated T cell survival, suppression of M1 macrophage activation, and modulation of dendritic cell function during gestation. Related references: PMID:27745970 PMID:28614294
• In vascular biology, ARG2 promotes endothelial cell senescence and inflammation via RPS6KB1 signaling and NOS3/eNOS dysfunction, and can inhibit autophagy independently of enzymatic activity. Related references: PMID:22928666 PMID:25484082
• It is involved in vascular smooth muscle cell senescence and apoptosis, and contributes to male and female sexual arousal by regulating NO in reproductive tissues. Related references: PMID:23832324 PMID:12859189

Experimental Guidance and Technical Tips

• Based on the immunogen sequence (amino acids 270-354 of human ARG2), the antibody is expected to detect full-length endogenous protein in Western blotting; a band at approximately 39 kDa is anticipated.
• For ELISA, consider using this antibody as a capture or detection reagent, but assay conditions such as coating and blocking should be optimized empirically.
• Given reported cross-reactivity with mouse and rat, the antibody may be suitable for rodent model studies; however, we recommend validating performance in the relevant sample system before large-scale use.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio bridges the gap between IVD raw-material needs and reliable supply, offering validated antibody pairs, optimized polyclonal antibodies, and bulk ancillary reagents to support your diagnostic development from concept to clinic. This anti-Arginase 2 (ARG2) rabbit polyclonal antibody targets a key enzyme in arginine metabolism and immune regulation, and CamelBio can assist in sourcing complementary reagents or custom production requirements for your specific workflow. Whether you need rare target raw materials or end-to-end technical consulting, CamelBio is committed to being your streamlined procurement ally.