APC Rabbit anti-Mouse CD96/TACTILE Monoclonal Antibody for FC - Q3U0X8

Core Product Specifications and Parameters

Biological Background: CD96/TACTILE Function and Localization

• T-cell surface protein tactile (CD96) is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily, featuring Ig-like domains, a signal peptide, and a transmembrane helix.
• CD96 mediates cell adhesion by interacting with PVR (poliovirus receptor) on target cells, enhancing NK cell-target conjugation during immune surveillance.
• The protein is expressed on activated T lymphocytes and natural killer (NK) cells, where it functions in late-phase immune responses, particularly in inflamed tissues after integrin-mediated extravasation.
• As a cell adhesion molecule, CD96 contributes to the dynamic interplay between immune cells and diseased cells, potentially influencing cytotoxicity and immune synapse formation.
• Structural studies indicate that CD96 contains multiple disulfide-bonded immunoglobulin-like domains essential for its adhesive properties.
• Post-translational modifications include glycosylation and disulfide bond formation, which are critical for protein folding and ligand interaction.

Experimental Guidance and Technical Tips

• This product is an APC-conjugated monoclonal antibody; recommended for direct flow cytometry applications.
• The immunogen corresponds to the extracellular domain (amino acids 35-536), enabling recognition of native surface CD96 on live cells.
• Validate in the relevant mouse model or cell type, as CD96 expression is limited to activated T and NK cells.
• Use appropriate isotype controls and Fc blocking to minimize non-specific binding.
• Titrate the antibody concentration for optimal staining, considering the activation state of your cells.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio delivers comprehensive IVD raw-material solutions for immune-oncology research, including this APC-conjugated anti-mouse CD96 monoclonal antibody for flow cytometry. As your one-stop partner, we offer validated antibody pairs, bulk reagents, and custom sourcing for rare targets like CD96, supporting your diagnostic development from concept to clinic. Our portfolio also includes ancillary reagents and technical consulting to streamline your assay workflows.