APC Rabbit anti-Mouse CD162/PSGL-1 Monoclonal Antibody for FC - Q3TA56

Core Product Specifications and Parameters

Biological Background: CD162/PSGL-1 Function and Localization

• Encoded by the Selplg gene in Mus musculus.
• Predicted molecular weight of 43.9 kDa (UniProt entry Q3TA56).
• Contains an N-terminal signal peptide and a single C-terminal transmembrane helix, indicating a type I membrane protein topology.
• Identified in mouse proteomics datasets (keyword evidence).
• Localizes to the membrane (inferred from transmembrane and signal peptide annotations).

Experimental Guidance and Technical Tips

• The immunogen (amino acids 18-320) spans the predicted extracellular domain after signal peptide cleavage, making this antibody suitable for detecting surface-expressed PSGL-1.
• For flow cytometry, optimize the antibody dilution using positive and negative control mouse cell lines or primary cells.
• Include appropriate isotype controls to account for non-specific binding, and consider using a viability dye to exclude dead cells.
• Verify reactivity in the relevant mouse strain or tissue type, as expression may vary.

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