APC Rabbit anti-Mouse CD155/Pvr mAb - Q91WP1

Core Product Specifications and Parameters

Biological Background: CD155/Pvr Function and Localization

• CD155/Pvr is encoded by the Pvr gene (also known as cd155, D7Ertd458e) in mice and is also referred to by multiple aliases including necl-5, Tage4, PVS, mE4, HVED, Taa1, and CD155.
• The protein localizes to the membrane, consistent with its annotation as a transmembrane receptor.
• It is a glycoprotein with a predicted signal peptide, disulfide bonds, and at least one transmembrane helix, features typical of cell surface receptors.
• The calculated molecular weight from the amino acid sequence is approximately 44.7 kDa (44655 Da), though glycosylation and other modifications may account for the observed 45 kDa band.
• UniProt keywords for Q91WP1 include: Disulfide bond, Glycoprotein, Membrane, Receptor, Signal, Transmembrane, Transmembrane helix.

Experimental Guidance and Technical Tips

• The immunogen comprises the extracellular domain (amino acids 29-348) of mouse CD155/Pvr, designed to target surface-exposed epitopes; consider this when planning blocking or competition experiments.
• As an APC-conjugated monoclonal antibody supplied for flow cytometry (FC), titrate the antibody to determine the optimal working concentration for your cell type and validate using positive/negative control cells expressing mouse CD155.
• Ensure single-cell suspensions and proper gating strategies, and include appropriate isotype controls to distinguish specific staining.
• If extending to other applications, verify compatibility and performance independently, as the product is validated only for FC.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio partners with diagnostic manufacturers and research labs to deliver a comprehensive portfolio of IVD raw materials, including validated antibodies, antigen pairs, and ancillary reagents. For studies involving immune checkpoint or cellular adhesion targets like CD155/Pvr, we provide one-stop sourcing from concept to clinic. Explore our monoclonal antibody offerings and custom solutions to accelerate your assay development and production.